Enhance tolerance to adverse conditions
Our technological platform promotes genetic variants with increased tolerance to production parameters such as a given toxic compound concentration (product, by-product or solutes in substrates), pH, temperature, etc.
Increase growth rate
The higher the production strain's growth rate, the higher the productivity of the bioprocess. The production strain's growth rate is therefore a critical factor for any bioprocess' feasibility and profitability. Our technological platform promotes genetic variants with the highest growth rate.
Growth on complex and alternative substrates
Evolving strains capable of growing on the appropriate feedstock greatly impacts any bioprocess' feasibility and profitability. Our technological platform enables the strain to adapt to complex growth media (including non-natural nutrients), substrate simplification (weaning from growth factor), alternative substrates, etc.
As they grow and thrive during industrial production, microbial strains are subject to evolution and natural selection. To ensure a steady production on an industrial scale, production strains must retain stability over evolutionary times. Our technological platform effectively creates stable strains for industrial applications.
Enabling technology for genetic engineering
Genetically engineered strains are designed to express a desired function. For this purpose, the genetic information coding for corresponding enzymes is introduced within a host organism that is expected to express properly the activity. However, regulation and expression of the altered part of the metabolic pathway is usually suboptimal, leading to a reduced growth rate when compared to the original host strain.
Because it enables the growth rate recovery of engineered strains, our approach is the ideal complement to genetic engineering in developing industrial strains.
We support the implementation of alternative metabolic pathways through the systematic improvement of heterologuous enzymatic activities.
Due to the dramatic reduction in sequencing costs, it is now possible to compare genomes of the ancestor and the evolved strain with the intention of identifying which are the mutations responsible for significant change in phenotype.
Our evolutionary devices, which control the selective pressure over a microbial population, are used as genetic engine to generate valuable information of industrial and academic interest.